Search on: 5-(5-FLUORO-2-OXO-1,2-DIHYDROINDOLYLIDENEMETHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID (2-DIETHYLAMINOETHYL)AMIDE 
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Descriptor English:   Sunitinib 
Descriptor Spanish:   Sunitinib 
Descriptor Portuguese:   Sunitinibe 
Synonyms English:   5-(5-Fluoro-2-oxo-1,2-dihydroindolylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide
SU 011248
SU 11248
SU-011248
SU-11248
SU011248
SU11248
Sunitinib Malate
Sutent  
Tree Number:   D03.383.129.578.823
D03.633.100.473.877
Definition English:   An indole and pyrrole derivative that inhibits VEGFR-2 and PDGFR BETA RECEPTOR TYROSINE KINASES. It is used as an antineoplastic agent for the treatment of GASTROINTESTINAL STROMAL TUMORS, and for treatment of advanced or metastatic RENAL CELL CARCINOMA. 
Pharmacological Action:   Antineoplastic Agents
Angiogenesis Inhibitors
Protein Kinase Inhibitors
 
History Note English:   2019 (2003) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   57545 
Unique Identifier:   D000077210 

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